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Quantitative analysis of thrombomodulin-mediated conversion of Protein C to APC: translation from in vitro to in vivo
Thrombomodulin-bound thrombin cleaves protein C (PC) zymogen in blood plasma producing activated protein C (APC), which exerts anti-coagulant, anti-inflammatory, anti-apoptotic and CNS-protective effects. Recombinant APC and thrombomodulin (TM) are both in clinical studies for management of acute co...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3443618/ https://ncbi.nlm.nih.gov/pubmed/22750541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2012.06.012 |
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