Anti-TNF treatment of IFN induced lupus nephritis reduces the renal macrophage response but does not alter glomerular immune complex formation

OBJECTIVE: To analyze the mechanism for the therapeutic effects of TNFα inhibition in a murine model SLE. METHODS: We used the IFN induced NZB/W model of SLE nephritis and treated mice with TNFR2-Ig after TNF expression was detected in the kidneys. Autoantibodies were measured by ELISA and autoantib...

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Main Authors: Bethunaickan, Ramalingam, Sahu, Ranjit, Liu, Zheng, Tang, Yi Ting, Huang, Weiqing, Edegbe, Osarieman, Tao, Haiou, Ramanujam, Meera, Madaio, Michael P., Davidson, Anne
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443508/
https://ncbi.nlm.nih.gov/pubmed/22674120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34553
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