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Anti-TNF treatment of IFN induced lupus nephritis reduces the renal macrophage response but does not alter glomerular immune complex formation
OBJECTIVE: To analyze the mechanism for the therapeutic effects of TNFα inhibition in a murine model SLE. METHODS: We used the IFN induced NZB/W model of SLE nephritis and treated mice with TNFR2-Ig after TNF expression was detected in the kidneys. Autoantibodies were measured by ELISA and autoantib...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3443508/ https://ncbi.nlm.nih.gov/pubmed/22674120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34553 |
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