Functional Specialization in Proline Biosynthesis of Melanoma

Proline metabolism is linked to hyperprolinemia, schizophrenia, cutis laxa, and cancer. In the latter case, tumor cells tend to rely on proline biosynthesis rather than salvage. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then t...

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Bibliografiske detaljer
Main Authors: De Ingeniis, Jessica, Ratnikov, Boris, Richardson, Adam D., Scott, David A., Aza-Blanc, Pedro, De, Surya K., Kazanov, Marat, Pellecchia, Maurizio, Ronai, Ze'ev, Osterman, Andrei L., Smith, Jeffrey W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443215/
https://ncbi.nlm.nih.gov/pubmed/23024808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045190
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