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Evolution of Bombesin Conjugates for Targeted PET Imaging of Tumors

Bombesin receptors are under intense investigation as molecular targets since they are overexpressed in several prevalent solid tumors. We rationally designed and synthesized a series of modified bombesin (BN) peptide analogs to study the influence of charge and spacers at the N-terminus, as well as...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Hanwen, Abiraj, Keelara, Thorek, Daniel L. J., Waser, Beatrice, Smith-Jones, Peter M., Honer, Michael, Reubi, Jean Claude, Maecke, Helmut R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443097/
https://ncbi.nlm.nih.gov/pubmed/23024746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044046
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