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Ca(2+) Regulation of Ion Transport in the Na(+)/Ca(2+) Exchanger
The binding of Ca(2+) to two adjacent Ca(2+)-binding domains, CBD1 and CBD2, regulates ion transport in the Na(+)/Ca(2+) exchanger. As sensors for intracellular Ca(2+), the CBDs form electrostatic switches that induce the conformational changes required to initiate and sustain Na(+)/Ca(2+) exchange....
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| Hlavní autor: | |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3442498/ https://ncbi.nlm.nih.gov/pubmed/22822067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R112.353573 |
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