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Ca(2+) Regulation of Ion Transport in the Na(+)/Ca(2+) Exchanger
The binding of Ca(2+) to two adjacent Ca(2+)-binding domains, CBD1 and CBD2, regulates ion transport in the Na(+)/Ca(2+) exchanger. As sensors for intracellular Ca(2+), the CBDs form electrostatic switches that induce the conformational changes required to initiate and sustain Na(+)/Ca(2+) exchange....
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3442498/ https://ncbi.nlm.nih.gov/pubmed/22822067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R112.353573 |
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