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Ca(2+) regulation in the Na(+)/Ca(2+) exchanger features a dual electrostatic switch mechanism
Regulation of ion-transport in the Na(+)/Ca(2+) exchanger (NCX) occurs via its cytoplasmic Ca(2+)-binding domains, CBD1 and CBD2. Here, we present a mechanism for NCX activation and inactivation based on data obtained using NMR, isothermal titration calorimetry (ITC) and small-angle X-ray scattering...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2732890/ https://ncbi.nlm.nih.gov/pubmed/19667209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902171106 |
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