Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy

Calcium current through voltage-gated calcium channels (VGCC) controls gene expression. Here, we describe a novel signalling pathway in which the VGCC Cacnb4 subunit directly couples neuronal excitability to transcription. Electrical activity induces Cacnb4 association to Ppp2r5d, a regulatory subun...

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Detalhes bibliográficos
Main Authors: Tadmouri, Abir, Kiyonaka, Shigeki, Barbado, Maud, Rousset, Matthieu, Fablet, Katell, Sawamura, Seishiro, Bahembera, Eloi, Pernet-Gallay, Karin, Arnoult, Christophe, Miki, Takafumi, Sadoul, Karin, Gory-Faure, Sylvie, Lambrecht, Caroline, Lesage, Florian, Akiyama, Satoshi, Khochbin, Saadi, Baulande, Sylvain, Janssens, Veerle, Andrieux, Annie, Dolmetsch, Ricardo, Ronjat, Michel, Mori, Yasuo, De Waard, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442274/
https://ncbi.nlm.nih.gov/pubmed/22892567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.226
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