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DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs
Here, we have characterized a step in translation initiation of viral and cellular mRNAs that contain RNA secondary structures immediately at the vicinity of their m(7)GTP cap. This is mediated by the DEAD-box helicase DDX3 which can directly bind to the 5′ of the target mRNA where it clamps the ent...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3442272/ https://ncbi.nlm.nih.gov/pubmed/22872150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.220 |
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