Mouse Strains with an Active H2-Ea Meiotic Recombination Hot Spot Exhibit Increased Levels of H2-Ea-Specific DNA Breaks in Testicular Germ Cells

We devised a sensitive method for the site-specific detection of rare meiotic DNA strand breaks in germ cell-enriched testicular cell populations from mice that possess or lack an active recombination hot spot at the H2-Ea gene. Using germ cells from adult animals, we found an excellent correlation...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Qin, Jian, Richardson, Laura L., Jasin, Maria, Handel, Mary Ann, Arnheim, Norman
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 2004
Sujets:	DNA Dynamics and Chromosome Structure
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC344187/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14749381/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.4.1655-1666.2004
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