Mouse Strains with an Active H2-Ea Meiotic Recombination Hot Spot Exhibit Increased Levels of H2-Ea-Specific DNA Breaks in Testicular Germ Cells

We devised a sensitive method for the site-specific detection of rare meiotic DNA strand breaks in germ cell-enriched testicular cell populations from mice that possess or lack an active recombination hot spot at the H2-Ea gene. Using germ cells from adult animals, we found an excellent correlation...

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Detalhes bibliográficos
Main Authors: Qin, Jian, Richardson, Laura L., Jasin, Maria, Handel, Mary Ann, Arnheim, Norman
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC344187/
https://ncbi.nlm.nih.gov/pubmed/14749381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.4.1655-1666.2004
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