Association Test Based on SNP Set: Logistic Kernel Machine Based Test vs. Principal Component Analysis

GWAS has facilitated greatly the discovery of risk SNPs associated with complex diseases. Traditional methods analyze SNP individually and are limited by low power and reproducibility since correction for multiple comparisons is necessary. Several methods have been proposed based on grouping SNPs in...

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Bibliografiske detaljer
Main Authors: Zhao, Yang, Chen, Feng, Zhai, Rihong, Lin, Xihong, Diao, Nancy, Christiani, David C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441747/
https://ncbi.nlm.nih.gov/pubmed/23028716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044978
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