PI3Kγ Drives Priming and Survival of Autoreactive CD4(+) T Cells during Experimental Autoimmune Encephalomyelitis

The class IB phosphoinositide 3-kinase gamma enzyme complex (PI3Kγ) functions in multiple signaling pathways involved in leukocyte activation and migration, making it an attractive target in complex human inflammatory diseases including MS. Here, using pik3cg (−/−) mice and a selective PI3Kγ inhibit...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Comerford, Iain, Litchfield, Wendel, Kara, Ervin, McColl, Shaun R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2012
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441529/
https://ncbi.nlm.nih.gov/pubmed/23028778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045095
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