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PI3Kγ Drives Priming and Survival of Autoreactive CD4(+) T Cells during Experimental Autoimmune Encephalomyelitis
The class IB phosphoinositide 3-kinase gamma enzyme complex (PI3Kγ) functions in multiple signaling pathways involved in leukocyte activation and migration, making it an attractive target in complex human inflammatory diseases including MS. Here, using pik3cg (−/−) mice and a selective PI3Kγ inhibit...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3441529/ https://ncbi.nlm.nih.gov/pubmed/23028778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045095 |
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