The HIV-1 protease inhibitor nelfinavir activates PP2 and inhibits MAPK signaling in macrophages: a pathway to reduce inflammation

The HIV-1 PI NFV has off-target effects upon host enzymes, including inhibition of the 20S proteasome, resulting in activation of PP1. HIV-1-associated monocyte/macrophage activation, in part a result of systemically elevated levels of microbial products including LPS, is associated with risk of mor...

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Detaylı Bibliyografya
Asıl Yazarlar: Wallet, Mark A., Reist, Caroline M., Williams, Julie C., Appelberg, Sofia, Guiulfo, Giorgio L., Gardner, Brent, Sleasman, John W., Goodenow, Maureen M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Leukocyte Biology 2012
Konular:
Inflammation, Extracellular Mediators, & Effector Molecules
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441314/
https://ncbi.nlm.nih.gov/pubmed/22786868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0911447
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