Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition

BACKGROUND: Pro-inflammatory stimuli, including cytokines like Interleukin-1β, Interleukin-6 and Interferon-γ, in the brain have been proposed to exacerbate existing Alzheimer’s disease (AD) neuropathology by increasing amyloidogenic processing of APP and promoting further Aβ accumulation in AD. On...

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Bibliographic Details
Main Authors: Chakrabarty, Paramita, Tianbai, Li, Herring, Amanda, Ceballos-Diaz, Carolina, Das, Pritam, Golde, Todd E
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441281/
https://ncbi.nlm.nih.gov/pubmed/22838967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-36
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