STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells During Acute Murine Graft Versus Host Disease

Acute graft versus host disease (GvHD) is a major cause of mortality in allogeneic bone marrow transplantation (BMT), for which administration of FoxP3(+) Treg cells has been proposed as a therapy. However, the phenotypic stability of Treg cells is controversial and cytokines that signal through the...

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Bibliographic Details
Main Authors:	Laurence, Arian, Amarnath, Shoba, Mariotti, Jacopo, Kim, Yong Chan, Foley, Jason, Eckhaus, Michael, O’Shea, John J., Fowler, Daniel H.
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3441059/ https://ncbi.nlm.nih.gov/pubmed/22921119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.05.027
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STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells During Acute Murine Graft Versus Host Disease

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