Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts

INTRODUCTION: Earlier, we showed that in cancer cells, AMP-activated kinase (AMPK) participates in a signal transduction pathway involving ATM-AMPK-p53/p21(cip1) which is activated by ionizing radiation (IR) to mediate G2-M arrest and enhanced cytotoxicity. We also observed that AMPK modulates ATM e...

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Detalhes bibliográficos
Main Authors: Storozhuk, Yaryna, Sanli, Toran, Hopmans, Sarah N, Schultz, Carrie, Farrell, Tom, Cutz, Jean-Claude, Steinberg, Gregory R, Wright, James, Singh, Gurmit, Tsakiridis, Theodoros
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439705/
https://ncbi.nlm.nih.gov/pubmed/22607554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-7-71
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