Urokinase-Deficient Mice Fail To Generate a Type 2 Immune Response following Schistosomal Antigen Challenge

Activated lymphocytes express urokinase-type plasminogen activator (uPA). Previous work suggests that uPA modulates T-lymphocyte responses. Mice deficient in uPA (uPA(−/−)) fail to generate type 1 (T1) immune responses during infection with Cryptococcus neoformans. Failure to generate either a T1 or...

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Detalhes bibliográficos
Main Authors: Gyetko, Margaret R., Sud, Sudha, Chensue, Stephen W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC343962/
https://ncbi.nlm.nih.gov/pubmed/14688127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.1.461-467.2004
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