Delayed Mortality and Attenuated Thrombocytopenia Associated with Severe Malaria in Urokinase- and Urokinase Receptor-Deficient Mice

We explored the role of urokinase and tissue-type plasminogen activators (uPA and tPA), as well as the uPA receptor (uPAR; CD87) in mouse severe malaria (SM), using genetically deficient (−/−) mice. The mortality resulting from Plasmodium berghei ANKA infection was delayed in uPA(−/−) and uPAR(−/−)...

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Detalhes bibliográficos
Main Authors: Piguet, Pierre Francois, Da Laperrousaz, Chen, Vesin, Christian, Tacchini-Cottier, Fabienne, Senaldi, Giorgio, Grau, Georges Emile
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC101654/
https://ncbi.nlm.nih.gov/pubmed/10858190
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