Blockade of adenosine A(2A) receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway

BACKGROUND AND PURPOSE: Blockade of adenosine A(2A) receptors (A(2A)R) affords robust neuroprotection in a number of brain conditions, although the mechanisms are still unknown. A likely candidate mechanism for this neuroprotection is the control of neuroinflammation, which contributes to the amplif...

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Autors principals: Simões, Ana Patrícia, Duarte, João A, Agasse, Fabienne, Canas, Paula Margarida, Tomé, Angelo R, Agostinho, Paula, Cunha, Rodrigo A
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439355/
https://ncbi.nlm.nih.gov/pubmed/22901528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-204
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