Caffeine acts through neuronal adenosine A(2A) receptors to prevent mood and memory dysfunction triggered by chronic stress

The consumption of caffeine (an adenosine receptor antagonist) correlates inversely with depression and memory deterioration, and adenosine A(2A) receptor (A(2A)R) antagonists emerge as candidate therapeutic targets because they control aberrant synaptic plasticity and afford neuroprotection. Theref...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Kaster, Manuella P., Machado, Nuno J., Silva, Henrique B., Nunes, Ana, Ardais, Ana Paula, Santana, Magda, Baqi, Younis, Müller, Christa E., Rodrigues, Ana Lúcia S., Porciúncula, Lisiane O., Chen, Jiang Fan, Tomé, Ângelo R., Agostinho, Paula, Canas, Paula M., Cunha, Rodrigo A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485143/
https://ncbi.nlm.nih.gov/pubmed/26056314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423088112
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