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Enhanced ATP release and CD73‐mediated adenosine formation sustain adenosine A(2A) receptor over‐activation in a rat model of Parkinson's disease
BACKGROUND AND PURPOSE: Parkinson's disease (PD) involves an initial loss of striatal dopamine terminals evolving into degeneration of dopamine neurons in substantia nigra (SN), which can be modelled by 6‐hydroxydopamine (6‐OHDA) administration. Adenosine A(2A) receptor blockade attenuates PD f...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6715785/ https://ncbi.nlm.nih.gov/pubmed/31220343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14771 |
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