Enhanced ATP release and CD73‐mediated adenosine formation sustain adenosine A(2A) receptor over‐activation in a rat model of Parkinson's disease

BACKGROUND AND PURPOSE: Parkinson's disease (PD) involves an initial loss of striatal dopamine terminals evolving into degeneration of dopamine neurons in substantia nigra (SN), which can be modelled by 6‐hydroxydopamine (6‐OHDA) administration. Adenosine A(2A) receptor blockade attenuates PD f...

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Udgivet i:Br J Pharmacol
Main Authors: Carmo, Marta, Gonçalves, Francisco Q., Canas, Paula M., Oses, Jean‐Pierre, Fernandes, Francisco D., Duarte, Filipe V., Palmeira, Carlos M., Tomé, Angelo R., Agostinho, Paula, Andrade, Geanne M., Cunha, Rodrigo A.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715785/
https://ncbi.nlm.nih.gov/pubmed/31220343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14771
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