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The role of autophagy in the pathogenesis of glycogen storage disease type II (GSDII)

Regulated removal of proteins and organelles by autophagy–lysosome system is critical for muscle homeostasis. Excessive activation of autophagy-dependent degradation contributes to muscle atrophy and cachexia. Conversely, inhibition of autophagy causes accumulation of protein aggregates and abnormal...

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Autors principals: Nascimbeni, A C, Fanin, M, Masiero, E, Angelini, C, Sandri, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438501/
https://ncbi.nlm.nih.gov/pubmed/22595755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.52
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