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Impaired autophagy contributes to muscle atrophy in glycogen storage disease type II patients

The autophagy-lysosome system is essential for muscle cell homeostasis and its dysfunction has been linked to muscle disorders that are typically distinguished by massive autophagic buildup. Among them, glycogen storage disease type II (GSDII) is characterized by the presence of large glycogen-fille...

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Hlavní autoři: Nascimbeni, Anna Chiara, Fanin, Marina, Masiero, Eva, Angelini, Corrado, Sandri, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494606/
https://ncbi.nlm.nih.gov/pubmed/22940840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.21691
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