Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate

Cerebral ischemia and excitotoxic injury induce transient or permanent bioenergetic failure, and may result in neuronal apoptosis or necrosis. We have previously shown that ATP depletion and activation of AMP-activated protein kinase (AMPK) during excitotoxic injury induces neuronal apoptosis by tra...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Davila, D, Connolly, N M C, Bonner, H, Weisová, P, Dussmann, H, Concannon, C G, Huber, H J, Prehn, J H M
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group 2012
विषय:
Original Paper
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438498/
https://ncbi.nlm.nih.gov/pubmed/22539004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.49
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