Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate

Cerebral ischemia and excitotoxic injury induce transient or permanent bioenergetic failure, and may result in neuronal apoptosis or necrosis. We have previously shown that ATP depletion and activation of AMP-activated protein kinase (AMPK) during excitotoxic injury induces neuronal apoptosis by tra...

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Detalhes bibliográficos
Main Authors: Davila, D, Connolly, N M C, Bonner, H, Weisová, P, Dussmann, H, Concannon, C G, Huber, H J, Prehn, J H M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438498/
https://ncbi.nlm.nih.gov/pubmed/22539004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.49
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