Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate

Cerebral ischemia and excitotoxic injury induce transient or permanent bioenergetic failure, and may result in neuronal apoptosis or necrosis. We have previously shown that ATP depletion and activation of AMP-activated protein kinase (AMPK) during excitotoxic injury induces neuronal apoptosis by tra...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Davila, D, Connolly, N M C, Bonner, H, Weisová, P, Dussmann, H, Concannon, C G, Huber, H J, Prehn, J H M
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2012
Gaiak:
Original Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438498/
https://ncbi.nlm.nih.gov/pubmed/22539004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.49
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