Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

Temporal lobe epilepsy is a common, chronic neurologic disorder characterized by recurrent spontaneous seizures. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate post-transcriptional expression of protein-coding mRNAs, which may have important roles in the pathogenesis of neurologic disor...

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Detalhes bibliográficos
Main Authors: Jimenez-Mateos, Eva M., Engel, Tobias, Merino-Serrais, Paula, McKiernan, Ross C., Tanaka, Katsuhiro, Mouri, Genshin, Sano, Takanori, O’Tuathaigh, Colm, Waddington, John L., Prenter, Suzanne, Delanty, Norman, Farrell, Michael A., O’Brien, Donncha F., Conroy, Ronán M., Stallings, Raymond L., deFelipe, Javier, Henshall, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438344/
https://ncbi.nlm.nih.gov/pubmed/22683779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2834
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