Rationally designed mutations convert complexes of human recombinant T cell receptor ligands into monomers that retain biological activity

Single-chain human recombinant T cell receptor ligands derived from the peptide binding/TCR recognition domain of human HLA-DR2b (DRA*0101/DRB1*1501) produced in Escherichia coli with and without amino-terminal extensions containing antigenic peptides have been described previously. While molecules...

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Detalhes bibliográficos
Main Authors: Huan, Jianya Y, Meza-Romero, Roberto, Mooney, Jeffery L, Chou, Yuan K, Edwards, David M, Rich, Cathleen, Link, Jason M, Vandenbark, Arthur A, Bourdette, Dennis N, Bächinger, Hans-Peter, Burrows, Gregory G
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438139/
https://ncbi.nlm.nih.gov/pubmed/22973070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jctb.1086
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