CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

BACKGROUND: The 8-aminoquinoline (8AQ) drug primaquine (PQ) is currently the only approved drug effective against the persistent liver stage of the hypnozoite forming strains Plasmodium vivax and Plasmodium ovale as well as Stage V gametocytes of Plasmodium falciparum. To date, several groups have i...

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Bibliografische gegevens
Hoofdauteurs: Pybus, Brandon S, Sousa, Jason C, Jin, Xiannu, Ferguson, James A, Christian, Robert E, Barnhart, Rebecca, Vuong, Chau, Sciotti, Richard J, Reichard, Gregory A, Kozar, Michael P, Walker, Larry A, Ohrt, Colin, Melendez, Victor
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2012
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438098/
https://ncbi.nlm.nih.gov/pubmed/22856549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-11-259
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