Akt Inhibits Apoptosis Downstream of BID Cleavage via a Glucose-Dependent Mechanism Involving Mitochondrial Hexokinases

The serine/threonine kinase Akt/protein kinase B inhibits apoptosis induced by a variety of stimuli, including overexpression or activation of proapoptotic Bcl-2 family members. The precise mechanisms by which Akt prevents apoptosis are not completely understood, but Akt may function to maintain mit...

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Bibliographic Details
Main Authors: Majewski, Nathan, Nogueira, Veronique, Robey, R. Brooks, Hay, Nissim
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC343797/
https://ncbi.nlm.nih.gov/pubmed/14701745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.2.730-740.2004
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