Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2

To elucidate the functions of the serine/threonine kinase Akt/PKB in vivo, we generated mice lacking both akt1 and akt2 genes. Akt1/Akt2 double-knockout (DKO) mice exhibit severe growth deficiency and die shortly after birth. These mice display impaired skin development because of a proliferation de...

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Detalhes bibliográficos
Main Authors: Peng, Xiao-ding, Xu, Pei-Zhang, Chen, Mei-Ling, Hahn-Windgassen, Annett, Skeen, Jennifer, Jacobs, Joel, Sundararajan, Deepa, Chen, William S., Crawford, Susan E., Coleman, Kevin G., Hay, Nissim
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196068/
https://ncbi.nlm.nih.gov/pubmed/12782654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1089403
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