Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells

Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types. Tumor cell-derived exosomes participate in many biological processes, including...

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Главные авторы:	S. Zhang, Y. Zhang, J. Qu, X. Che, Y. Fan, K. Hou, T. Guo, G. Deng, N. Song, C. Li, X. Wan, X. Qu, Y. Liu
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Associação Brasileira de Divulgação Científica 2017-11-01
Серии:	Brazilian Journal of Medical and Biological Research
Предметы:	Cetuximab Exosome PTEN Akt Colon cancer
Online-ссылка:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000100609&lng=en&tlng=en
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