Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells
Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types. Tumor cell-derived exosomes participate in many biological processes, including...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , , , , , , , , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
Associação Brasileira de Divulgação Científica
2017-11-01
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| سلاسل: | Brazilian Journal of Medical and Biological Research |
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000100609&lng=en&tlng=en |
| الوسوم: |
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