Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells

Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types. Tumor cell-derived exosomes participate in many biological processes, including...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	S. Zhang, Y. Zhang, J. Qu, X. Che, Y. Fan, K. Hou, T. Guo, G. Deng, N. Song, C. Li, X. Wan, X. Qu, Y. Liu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Associação Brasileira de Divulgação Científica 2017-11-01
Schriftenreihe:	Brazilian Journal of Medical and Biological Research
Schlagworte:	Cetuximab Exosome PTEN Akt Colon cancer
Online-Zugang:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000100609&lng=en&tlng=en
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