Selective inhibition of CD4(+) T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

Bromodomain-containing proteins bind acetylated lysine residues on histone tails and are involved in the recruitment of additional factors that mediate histone modifications and enable transcription. A compound, I-BET-762, that inhibits binding of an acetylated histone peptide to proteins of the bro...

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Detalles Bibliográficos
Autores principales: Bandukwala, Hozefa S., Gagnon, John, Togher, Susan, Greenbaum, Jason A., Lamperti, Edward D., Parr, Nigel J., Molesworth, Amy M. H., Smithers, Nicholas, Lee, Kevin, Witherington, Jason, Tough, David F., Prinjha, Rab K., Peters, Bjoern, Rao, Anjana
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437860/
https://ncbi.nlm.nih.gov/pubmed/22912406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212264109
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