Selective inhibition of CD4(+) T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

Bromodomain-containing proteins bind acetylated lysine residues on histone tails and are involved in the recruitment of additional factors that mediate histone modifications and enable transcription. A compound, I-BET-762, that inhibits binding of an acetylated histone peptide to proteins of the bro...

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Bibliografske podrobnosti
Main Authors: Bandukwala, Hozefa S., Gagnon, John, Togher, Susan, Greenbaum, Jason A., Lamperti, Edward D., Parr, Nigel J., Molesworth, Amy M. H., Smithers, Nicholas, Lee, Kevin, Witherington, Jason, Tough, David F., Prinjha, Rab K., Peters, Bjoern, Rao, Anjana
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437860/
https://ncbi.nlm.nih.gov/pubmed/22912406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212264109
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