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Selective inhibition of CD4(+) T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors
Bromodomain-containing proteins bind acetylated lysine residues on histone tails and are involved in the recruitment of additional factors that mediate histone modifications and enable transcription. A compound, I-BET-762, that inhibits binding of an acetylated histone peptide to proteins of the bro...
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| Main Authors: | , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437860/ https://ncbi.nlm.nih.gov/pubmed/22912406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212264109 |
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