Selective inhibition of CD4(+) T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

Bromodomain-containing proteins bind acetylated lysine residues on histone tails and are involved in the recruitment of additional factors that mediate histone modifications and enable transcription. A compound, I-BET-762, that inhibits binding of an acetylated histone peptide to proteins of the bro...

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Main Authors: Bandukwala, Hozefa S., Gagnon, John, Togher, Susan, Greenbaum, Jason A., Lamperti, Edward D., Parr, Nigel J., Molesworth, Amy M. H., Smithers, Nicholas, Lee, Kevin, Witherington, Jason, Tough, David F., Prinjha, Rab K., Peters, Bjoern, Rao, Anjana
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2012
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437860/
https://ncbi.nlm.nih.gov/pubmed/22912406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212264109
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