Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2

We assessed somatic alleles of six receptor tyrosine kinase genes mutated in lung adenocarcinoma for oncogenic activity. Five of these genes failed to score in transformation assays; however, novel recurring extracellular domain mutations of the receptor tyrosine kinase gene ERBB2 were potently onco...

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Main Authors: Greulich, Heidi, Kaplan, Bethany, Mertins, Philipp, Chen, Tzu-Hsiu, Tanaka, Kumiko E., Yun, Cai-Hong, Zhang, Xiaohong, Lee, Se-Hoon, Cho, Jeonghee, Ambrogio, Lauren, Liao, Rachel, Imielinski, Marcin, Banerji, Shantanu, Berger, Alice H., Lawrence, Michael S., Zhang, Jinghui, Pho, Nam H., Walker, Sarah R., Winckler, Wendy, Getz, Gad, Frank, David, Hahn, William C., Eck, Michael J., Mani, D. R., Jaffe, Jacob D., Carr, Steven A., Wong, Kwok-Kin, Meyerson, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437859/
https://ncbi.nlm.nih.gov/pubmed/22908275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203201109
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