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Structure-based design of a pathway-specific nuclear import inhibitor
Kapβ2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx((2–5))PY motif. Here we show that Kapβ2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437620/ https://ncbi.nlm.nih.gov/pubmed/17435768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1229 |
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