Inhibitors of Hypoxia-Inducible Factor 1 Block Breast Cancer Metastastic Niche Formation and Lung Metastasis

Intratumoral hypoxia, a frequent finding in metastatic cancer, results in the activation of the hypoxia-inducible factors (HIFs). HIFs are implicated in many steps of breast cancer metastasis, including metastatic niche formation through induction of lysyl oxidase (LOX) and lysyl oxidase-like (LOXL)...

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Bibliographic Details
Main Authors: Wong, Carmen Chak-Lui, Zhang, Huafeng, Gilkes, Daniele M., Chen, Jasper, Wei, Hong, Chaturvedi, Pallavi, Hubbi, Maimon E., Semenza, Gregg L.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437551/
https://ncbi.nlm.nih.gov/pubmed/22231744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-011-0855-y
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