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Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation
Calcium binding to the regulatory domain of cardiac troponin C (cNTnC) causes a conformational change that exposes a hydrophobic surface to which troponin I (cTnI) binds, prompting a series of protein-protein interactions that culminate in muscle contraction. A number of cTnC variants that alter the...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437384/ https://ncbi.nlm.nih.gov/pubmed/22591429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3003007 |
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