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A structural and functional perspective into the mechanism of Ca(2+)-sensitizers that target the cardiac troponin complex
The Ca(2+) dependant interaction between troponin I (cTnI) and troponin C (cTnC) triggers contraction in heart muscle. Heart failure is characterized by a decrease in cardiac output, and compounds that increase the sensitivity of cardiac muscle to Ca(2+) have therapeutic potential. The Ca(2+)-sensit...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2975748/ https://ncbi.nlm.nih.gov/pubmed/20801130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.08.019 |
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