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A structural and functional perspective into the mechanism of Ca(2+)-sensitizers that target the cardiac troponin complex

The Ca(2+) dependant interaction between troponin I (cTnI) and troponin C (cTnC) triggers contraction in heart muscle. Heart failure is characterized by a decrease in cardiac output, and compounds that increase the sensitivity of cardiac muscle to Ca(2+) have therapeutic potential. The Ca(2+)-sensit...

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Bibliografske podrobnosti
Main Authors: Robertson, Ian M., Sun, Yin-Biao, Li, Monica X., Sykes, Brian D.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975748/
https://ncbi.nlm.nih.gov/pubmed/20801130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.08.019
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