Toxic effects of nicotinamide methylation on mouse brain striatum neuronal cells and its relation to manganese

OBJECTIVE: It is well known that manganese (Mn) exposure is involved in parkinsonism. The aim of our study was to test the hypotheses that Mn affects nicotinamide N-methyltransferase (NNMT) activity, increases the metabolism of nicotinamide (NA) to 1-methylnicotinamide (MNA), and leads to neurocytot...

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Autori principali: Mori, Yayoi, Sugawara, Akiko, Tsuji, Masayoshi, Kakamu, Takeyasu, Tsuboi, Satoshi, Kanda, Hideyuki, Hayakawa, Takehito, Fukushima, Tetsuhito
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Japan 2012
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Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437358/
https://ncbi.nlm.nih.gov/pubmed/22249857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12199-011-0262-6
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