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Role of the Second Extracellular Loop of Adenosine Receptors in Agonist and Antagonist Binding: ANALYSIS OF CHIMERIC A(1)/A(3) ADENOSINE RECEPTORS()

Adenosine receptor (AR) agonists and antagonists are ~100-fold and 100,000-fold, respectively, more potent at the bovine A(1)AR as compared to the rat A(3)AR. To determine regions of ARs involved in ligand recognition, chimeric receptors composed of bovine A(1)AR and rat A(3)AR sequence were constru...

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Autors principals: Olah, Mark E., Jacobson, Kenneth A., Stiles, Gary L.
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437327/
https://ncbi.nlm.nih.gov/pubmed/7929142
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