Absence of R140Q mutation of isocitrate dehydrogenase 2 in gliomas and breast cancers

Somatic mutations of isocitrate dehydrogenase (IDH)-1 and IDH2 proteins have been described in gliomas. The mutations target the R132 amino acid residue and the R172 residue in IDH1 and IDH2, respectively. The same mutations were observed in acute myeloid leukemias with normal karyotype, but a new m...

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Bibliografiske detaljer
Main Authors: RAYNAUD, STÉPHANE, CARBUCCIA, NADINE, COLIN, CAROLE, ADÉLAÏDE, JOSÉ, MOZZICONACCI, MARIE-JOELLE, METELLUS, PHILIPPE, CHINOT, OLIVIER, BIRNBAUM, DANIEL, CHAFFANET, MAX, FIGARELLA-BRANGER, DOMINIQUE
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436391/
https://ncbi.nlm.nih.gov/pubmed/22966399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol_00000156
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