Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications

Mutations in isocitrate dehydrogenase (IDH) are commonly observed in lower-grade glioma and secondary glioblastomas. IDH mutants confer a neomorphic enzyme activity that converts α-ketoglutarate to an oncometabolite D-2-hydroxyglutarate, which impacts cellular epigenetics and metabolism. IDH mutatio...

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Vydáno v:Biomedicines
Hlavní autoři: Liu, Yang, Lang, Fengchao, Chou, Fu-Ju, Zaghloul, Kareem A., Yang, Chunzhang
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554955/
https://ncbi.nlm.nih.gov/pubmed/32825279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines8090294
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