The novel combination of sirolimus and bortezomib prevents graft-versus-host disease but maintains the graft-versus-leukemia effect after allogeneic transplantation

BACKGROUND: We have previously shown that bortezomib induces a depletion of alloreactive T cells and allows the expansion of T cells with suppressive properties. In the current study, we analyzed the potential synergistic effect of bortezomib in conjunction with sirolimus in order to reduce-graft-ve...

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Detalhes bibliográficos
Main Authors: Caballero-Velázquez, Teresa, Sánchez-Abarca, Luis Ignacio, Gutierrez-Cosio, Silvia, Blanco, Belén, Calderon, Cristina, Herrero, Carmen, Carrancio, Soraya, Serrano, Concepción, del Cañizo, Consuelo, San Miguel, Jesús F., Pérez-Simón, José A.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2012
Assuntos:
Original Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436233/
https://ncbi.nlm.nih.gov/pubmed/22532520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.058677
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