A Novel Mechanism Involving Four-and-a-half LIM Domain Protein-1 and Extracellular Signal-regulated Kinase-2 Regulates Titin Phosphorylation and Mechanics

Understanding mechanisms underlying titin regulation in cardiac muscle function is of critical importance given recent compelling evidence that highlight titin mutations as major determinants of human cardiomyopathy. We previously identified a cardiac biomechanical stress-regulated complex at the ca...

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Detalhes bibliográficos
Main Authors: Raskin, Anna, Lange, Stephan, Banares, Katherine, Lyon, Robert C., Zieseniss, Anke, Lee, Leonard K., Yamazaki, Katrina G., Granzier, Henk L., Gregorio, Carol C., McCulloch, Andrew D., Omens, Jeffrey H., Sheikh, Farah
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436149/
https://ncbi.nlm.nih.gov/pubmed/22778266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.372839
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