A Novel Mechanism Involving Four-and-a-half LIM Domain Protein-1 and Extracellular Signal-regulated Kinase-2 Regulates Titin Phosphorylation and Mechanics

Understanding mechanisms underlying titin regulation in cardiac muscle function is of critical importance given recent compelling evidence that highlight titin mutations as major determinants of human cardiomyopathy. We previously identified a cardiac biomechanical stress-regulated complex at the ca...

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Библиографические подробности
Главные авторы: Raskin, Anna, Lange, Stephan, Banares, Katherine, Lyon, Robert C., Zieseniss, Anke, Lee, Leonard K., Yamazaki, Katrina G., Granzier, Henk L., Gregorio, Carol C., McCulloch, Andrew D., Omens, Jeffrey H., Sheikh, Farah
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436149/
https://ncbi.nlm.nih.gov/pubmed/22778266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.372839
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