Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency

NOTCH1 pathway activation contributes to the pathogenesis of over 60% of T-cell acute lymphoblastic leukemia (T-ALL). While Notch is thought to exert the majority of its effects through transcriptional activation of Myc, it also likely has independent roles in T-ALL malignancy. Here, we utilized a z...

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Autors principals: Blackburn, Jessica S., Liu, Sali, Raiser, David M., Martinez, Sarah A., Feng, Hui, Meeker, Nathan D., Gentry, Jeffery, Neuberg, Donna, Look, A. Thomas, Ramaswamy, Sridhar, Bernards, Andre, Trede, Nikolaus S., Langenau, David M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435461/
https://ncbi.nlm.nih.gov/pubmed/22538478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.116
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